The English word that has the most definitions is “Set” which has 464 meanings in the Oxford English Dictionary. The word”Run” is a distant second, with 396. Other notable multiple meaning words are “go” with 368, “take” with 343, “stand” with 334, “get” with 289, “turn” with 288, “put” with 268, “fall” with 264, and “strike” with 250.
See the full list of definitions for the word “set” on Dictionary.com and The Free Dictionary.
Source: Dictionary.com