The Original 7Up Contained Lithium

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7 Up was created by Charles Leiper Grigg, who launched his St. Louis-based company The Howdy Corporation in 1920. Grigg came up with the formula for a lemon-lime soft drink in 1929. The product, originally named “Bib-Label Lithiated Lemon-Lime Soda”, was launched two weeks before the Wall Street Crash of 1929. It contained lithium citrate, a mood-stabilizing drug, until 1950. It was one of a number of patent medicine products popular in the late-19th and early-20th centuries. As the drink grew more and more popular, the original name was changed to 7Up  Lithiated Lemon-Lime Soda and then simply  7UP.

Source: Wikipedia7Up.com