Premarin is the commercial name for compound drug consisting primarily of conjugated estrogens. Isolated from mare’s urine (PREgnant MARes’ urINe), it is manufactured by Wyeth Pharmaceuticals. The drug is a form of hormone replacement therapy and is used most commonly in post menopausal women who have had a hysterectomy.
Premarin is the subject of some controversy. Animal rights groups and those opposing the industry claim that animal husbandry and urine collection methods used in Premarin’s production cause undue stress and suffering to the mares involved. Allegations of abuse range from concern over stall size, access to water, exercise, cruel treatment, collection system and continuous breeding cycles, resulting in premature death for thousands of mares and foals. Some claim the numbers are more accurately in the millions.